Can you formulate a model for the airline industry using the integer programming model?

Can you formulate a model for the airline industry using the integer programming model?

That was the question asked by the professor after I wrote the reply listed below to her question.

An integer programming model would be utilized in scheduling for high demand space in government buildings or classrooms or it can be used in high level budgeting for construction projects. Airlines companies can use integer programming models for determining their plane routing in order to maximize the best methodology for planning the flight patterns of the planes. 

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