Harris (1966) measured the number of genotypes at the alkaline phosphatase locus in the English population. These are three alleles, designated F, I, and S (for fast, intermediate, and slow mobility in an electrophoretic apparatus).

SS     SF    FF    SI     FI    II

141  111   28     32    15     5

  1. what are the observed frequencies of the six genotypes?
  2. what are the observed allele frequencies for the three alleles?
  3. what are the Hardy-Weinberg equilibrium frequencies of the genotypes?
  4. what are the Hardy-Weinberg equilibrium frequencies of the allele?
  5. what is the total observed heterozygosity (i.e. the frequency of all heterozygotes)?
  6. what is the total heterozygosity at the Hardy-Weinberg equilibrium?
  7. Compare the observed and equilibrium heterozygosities. Does this suggest to you any departures from hardy-Weinberg conditions, and if so, what kind of departure?
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